Khameleon is very strong for Sub, she gives him crazy mix and multiple mind games:
Mileena: gives him mix off F123xxAirSai's/F12xxBallRoll
B34xxAirSai's/B3xxBallRoll
Jade: gives him very good blockstring pressure and mix, you can do B3/B2 into Glaives then do B3/B2 again while poking the spot after first glaive they can hit Khameleon (if they are fast and know it's coming) but you can also backdash punish. Jade Glow has real projectile immunity unlike Sub/Motaro. Jade gives crazy damage (over 40% midscreen and it's hot confirmable from B3/B2 mix)
Kitana Disguise: gives SubZero so much mind games, safety and even mix. Her Fan Toss(R1) is -6 on block and double hitting close up and a MID. This makes his B2 a safe launcher and his Gaps safe if you bait the Armor gap in B34/21 and Fan Toss breaks armor. Fan Toss launches midscreen but doesn't have high damage follow-ups but in the corner you get big boy meterless damage. Fan Lift is probably one of the best moves in the game, you can cancel recovery of anything! Not just cancel recovery but make a mind game with the distance you fly. You can combo off F12xxFanLift if you use IA Divekick, or do a frame trap. Fan Lift makes your special moves on block completely safe and steals turn depending on what you do, Slide, Clone, Divekick all safe using Fan Lift.
Khameleon is 200% Sub Zero's Strongest Kameo if you can master her. It's easy to Switch to the variation you want. Hold R1 right as the Kameo move is ending. So do B3/B2 into Jade Glaives and Hold R1 and your instantly Kitana Disguise and can blockstring pressure into Fan Lift shenanigans or -6 on block Fan Toss that launches on hit and if you hold R1 your in Mileena and get Air Sai's for easy combo follow up into B34/B3xxBallRoll or F123xxAirSai's/F12xxBallRoll mix.
Everything she has comes back instantly and all variations are very strong. Every variation has launchers so there's always damage and setplay into mind games or 50/50's.
To my knowledge Sub Zero is one of the few characters that doesn't get Throw Combos with Khameleon but he gets plenty. I actually feel like he's not trash using Khameleon. More like maining Khameleon with Sub as a backup.