No there are people capable of taking him out... Despero, Amazo, ANY mystical/magical threat that is remotely powerful, etc. Cheetah managed to break his skin and possess him because she's the avatar of a cheetah deity. And that's not too crazy of a concept. At least for me. They've dumbed down Superman's ridiculous power levels in the New 52, so that's helped a lot.
I am noticing that everybody in New 52 is a lot stronger and Superman is dumbed down a bit (he had to be, in theory, very few chars can beat him). What's to stop superman from flying away from cheetah and just chucking meteorites at her? Or super speed behind her and snap her neck? How can she stop frost breath, eye lasers? Same shit as Injustice, fly away and zone her the fuck out. I don't see Cheetah (realistically) beating Kal El.
Amazo I agree w/, forgot about him. Flash/WW seem to have really leveled up
Bro Namath Look up Superman's powers, there is no way, in theory he should lose minus VERY few people (including Darkseid, Doomsday). He was made way too strong. I get it, I know it's a comic and in order to sell more you have to weaken him sometimes, but very few chars should beat him. Shit, in all honesty, Black Adam should be ruling the world. Nobody should ever touch him