It's fine. I just let Batman go through Endless for the 200 Arkham Villains while I played with myself. The rest of the stuff I had to manually do, though.
1. AI is your best friend for all types of damage dealt/enemies defeated types of things. Just let it (or yourself) run through Endless Towers while you're doing other stuff.
You have to be there to press X to continue after the fight though..
For my Supergirl one, I just play the MV at the top right of the multiverses screen, the one with the boss... I just kept replaying the boss fight and I got a lotta unlocks. 1 boss fight = 1 Multiverse event so i got that 200 multiverse event completions in like two days. You also get that damage thing and a lot of motherboxes which you might get rare/epic gear from
Yeah. Like, while I'm doing essays or cleaning/eating I'll let the AI do boss battles from the Top Right MV. That's why I have so many Silver Motherboxes.