Finishing up my research today, (including Kenshi), I will post it soon. This lab work I'm doing is good learning for me on going against everyone's wakeups, not only with Kano, but I'm testing it for every one of my characters.
What I'm testing against is EX wake-ups, not regular wake-ups, because you wouldn't be able to tell the difference in the reaction time after air throw and change your move mid-reaction. Also if something beats a move EX wake-up, it'll definitely beat the same move regular wake-up. And I say always be prepared because if they have meter, they probably will use it.
So far what I'm finding is this 50/50 doesn't work too well against most EX wakeups. What I'm trying to get is a basic idea of what you should do always in general once you knock them down for each character. I'm testing it with an air throw and what to do also after doing a move with less Kano hit advantage.
For example, against Cyrax, his wake-up system is one of the best in the game. He has overhead, low, anti-air, and an EX teleport against jumping in. So pretty much, this Kano 50/50 will be useless and get you blown up if they do any wake up. Even if they don't do a wake-up, then maybe I can see this possibly working. But how do you know what they're going to do? The best for him is to stay out farther than mid screen once you knock him down so you avoid his 50/50 ground wakeup, and also be in the air so you can judge what do. So pretty much, Kano against Cyrax, after an air throw, jump back fast, or jump back fast and air ball, and it will whiff or stuff Cyrax's EX wake-ups at least 80% of the time.