Hate to be that guy, but most of the 16 bit commentary I remember involves an awful lot of shit talking and just shouting as loud as possible. Considering I'll actually be watching this and not competing, it's probably a no from me for 16 bit. If 16 bit can actually turn down the screams, bias and trash and delivery consistent "professional" commentary then maybe, but if you're all rooting for him for those reasons then please god not at MLG. Also, I want to see 16 bit's Catwoman on stream.
From what I've seen, my choices would be Tom Brady providing he's not being emo (if he's not competing then there's no risk of going out early) especially as he's done MLG before and handled it really well, DMS who's been fantastic and can sell the MLG suits with ease (was it KIT he was suited up?), and Sabin who can also be incredibly professional on the mic while still sounding hype. Those 3 on rotation would be great, with TTG doing hype on-the-side interviews (yes I love TTG's style - his personality comes across as incredibly excited rather than slightly aggressive).
edit: even if you did a colou and play-by-play pairing (with 16 bit being the colour commentator), I would still worry that he will just end up shouting over everything. This is not professional wrestling, and even then those commentators know how to delivery story bites without being overbearing.