don't try to hold it like some people hold the 360 one with the index and middle on the bumper and trigger, just use your index finger to hit R2 otherwise it will probably feel really weird.
other than that...if you've played videogames before you really shouldn't have any issues. Oh and get ready to wear down the d-pad a bit before you really start to get smooth with it, the stock texture can be kind of rough initially. I had come pretty close to blisters for the first month of playing this game, as I hadn't ever had a use for the d-pad for the games I played.