I think I'm gonna wait till the GOTY edition comes out cause I doubt even Bethesda can let this one slide.
"On PlayStation 3, however, it's a different story. Due to what we've been told are incompatibilities between that console's memory distribution and the way Skyrim's engine handles its dynamic, persistent content, anyone who plays more than 30-40 hours of Skyrim -- a game meant to span hundreds of hours -- will inevitably reach a point at which the game simply becomes unplayable. The action slows to a crawl, items disappear, quests stop working. This, despite Bethesda's assurances that Skyrim would resolve Fallout 3's PS3-specific issues; even more infuriatingly, they made the press complicit in covering that version's flaws by distributing the 360 and Windows versions for review, "neglecting" to ship PS3 copies until Skyrim's launch."
That was on ign.com about the problem.