The point of 2,2 xx Freeze, JIP b+1,2,1 isn't to get your opponent into some kind of mixup. If the opp is dumb enough to get hit by whatever follow-up you do, that's just a bonus. The point of it is to remove any wake-up options from the opp, and to build meter while taking a bit of chip (to make up the dmg). If you do 2,2,4 xx Clone or 2,1,2 xx Clone, it actually makes it 1% more dmg than the JIP 2,1,4 xx Slide staple.
I often use b+1,2,1 as a combo-ender, and then start up 2,1 pressure/mixups. It's especially good in the corner, because then you can do 2,1,2 xx Clone for the nice setups you get from it.
I don't get a lot of Sub players... They seem to think Sub only works one way, and that they have to choose between his tools and only stick to one thing at a time. The new BnB came out, and people started saying "So do I stop using 2,2 now?" and with this option people say "No no, 2,1,4 xx Slide is so much better!" Why not use a bit of everything, and play it by ear? Go with what works in certain situations.
Having said that, I actually like it when some Sub players decide they don't like certain tactics and won't use them, because it means each Sub player becomes more unique, and shows that Sub-Zero isn't as one-dimentional as a lot of people seem to think.