Dude I remember the totems being absolutely brutal, the one that would explode and literally do like 90% of your health.
But my go to is always to pick Jade because she can spam glaives and her purple will stop most of the random stuff from hitting you. And you can always choose the option to do the tower solo so you can optimize your tag outs for healing and not have to worry about the other player being whack. I pick my main and Jade or double up on my main and that usually handles it. Just keep in mind that you're playing like 5 rounds in one sitting if doing it by yourself.