Oh it's hella fun man. Costum variations is what made me comeback to the game. 22121 is such a strong mix with so many options. Also very easy hit-confirmable if they are afraid of cmd grab and get hit in the middle of the string. U can easily react and end ur attack in gotcha grab/bf2 etc.
Nvm after some labbing - there are few chars like sub/sonya/cetrion/erron/cage that can low profile out of 221 despite the fact that all fallow up hits after 2(high) are mids and jails on REST of the cast... NRS with its "Classic" hitbox issues lol