I have lost some matches where the big combo was a bulk of the comeback. An example of someone else screwing up big combo, recently I was playing a match as Human Smoke vs a Kung Lao player and was caught in a spin inf early on that they botched eventually in the corner, when the spin missed I got HK, LP, JK, TP, spear, 3 hit, relaunch 3 hit, JK, RH, run in LK in corner for 74%, basically evened the match out but I still lost since I was at danger. I tried to go for a break in the relaunch because it would have been 100% =)